金沙990线路检测(中国百科)有限公司-Gaming Group

教育经历:

2004-08 至 2008-07, 北京大学, 细胞生物学, 博士
2000-09 至 2003-07, 中国科学院动物研究所, 细胞生物学, 硕士
1996-09 至 2000-07, 中国农业大学, 动物生理与生化, 学士

工作经历:

2025-08 至 今, 北京大学, 金沙990线路检测, 研究员
2010-10 至2025-8, 北京大学, 金沙990线路检测, 副研究员
2008-10 至 2010-10, 北京大学 博士后

      长期关注人多能干细胞向免疫细胞的定向分化，包括T淋巴细胞和嗜酸性粒细胞。希望在体外诱导产生功能性T细胞和安全型嗜酸性粒细胞，为未来治疗肿瘤提供理想的免疫细胞来源。

1. Zhen Liu; Haoyun Li; Zhaoya Gao; Ruoqi Cheng; Jiahua Lu; Xuan Che; Jiebin Dong; Zilong Wang; Zejia Cui; Jin Gu; Yun Bai; Cheng Li; Yinan Liu; Chengyan Wang✱; Hongkui Deng✱. IL-12 and GMCSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy, Frontier in Immunology, 2025, 16(1684842)

2. TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors.Zhu S, Zhou Z, Gu R, Zhao Z, Zhang Y, Miao Y, Lei Q, Liu T, Wang G, Dai C, Huo Y, You J, Lv L, Li C, Yin M, Wang C✱, Deng H✱. Experimental Hematology & Oncology. 2025 1;14(1):26. doi: 10.1186/s40164-025-00613-y.

3. Generation of Dual-Attribute iTNK Cells from hPSCs for Cancer Immunotherapy. Yingfeng Zhang, Yuanyuan He, Chenyi Dai, Zhengyang Zhou, Yudi Miao, Zixin Zhao, Qi Lei, Cheng Li, Chengyan Wang*, Hongkui Deng*. Cell Reports Methods. 2024 16.

4. Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors. Weifeng Lai, Huangfan Xie, Yuting Liu, Feng Zheng, Yingfeng Zhang, Chengyan Wang✱, Hongkui Deng✱. Stem Cell Reports. 2021 13;16(7):1697-1704.

5. Targeting JNK pathway promotes human hematopoietic stem cell expansion. Xiong Xiao,Weifeng Lai,Huangfan Xie,Yang Liu,Chengyan Wang✱, Hongkui Deng✱. Cell Discovery.2019:5:2. s41421-018-0072-8.

6. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Yang Yang,Bei Liu,Jun Xu,Jinlin Wang, Jun Wu, Cheng Shi,Chengyan Wang, Weifeng Lai,Jialiang Zhu,Liang Xiong,Dicong Zhu,Xiang Li,Weifeng Yang,Takayoshi Yamauchi,Atsushi Sugawara,Zhongwei Li,Fangyuan Sun, Huan Shen, Juan Carlos Izpisua Belmonte,Hongkui Deng. Cell.2017 6;169(2):243-257.

7. TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy. Chengyan Wang, Xuming Tang, Xiaomeng Sun, Zhenchuan Miao, Yaxin Lv, Yanlei Yang, Huidan Zhang, Pengbo Zhang, Yang Liu, Liying Du, Yang Gao, Ming Yin, Mingxiao Ding, Hongkui Deng. Cell Research. 2012 22(1):194-207.

8. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Chengyan WANG, Faloon PW, Zhijia Tan, Yaxin L, Pengbo Zhang, Yu Ge, Hongkui Deng, Jinwei Xiong. Blood. 2007 15;110(10):3601-9.

9. Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro. Gewei Lian✱, Chengyan Wang✱,Chunbo Teng,Cong Zhang,Liying Du,Qian Zhong,Chenglin Miao,Mingxiao Ding,Hongkui Deng. Experimental Hematology.2006 34(3):348-58.

10. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Pengbo Zhang,Jian Li,Zhijia Tan,Chengyan Wang,Ting Liu, Lin Chen,Jun Yong,Wei Jiang,Xiaomeng Sun,Liying Du,Mingxiao Ding,Hongkui Deng. Blood. 2008 15;111(4):1933-41.

11. CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo. Lei Xu,Huan Yang,Yang Gao,Zeyu Chen,Liangfu Xie,Yulin Liu, Ying Liu,Yiming Shao,Bin Zhang,Chengyan Wang,Hu Chen,Hongkui Deng.Molecule Therapy. 2017 2;25(8):1782-1789.

12. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong,Hongkui Deng,Richard A Flavell,Carlos A Guzman,Markus G Manz,Sean Stevens,Hergen Spits,Anja U van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler. Cell Host Microbe. 2009 23;6(1):5-9.